Authors: Shrivastav, P., Fois, M., Ibrahim, M., Zhang, W., An, J., Kobyra, J. A., & Li, Y.-R.
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- md.ibrahim@cnsu.edu
- 9700 W Taron Dr, Elk Grove, CA 95757
Md Ibrahim, Ph.D., MPS
Assistant Professor
Department of Pharmaceutical Science
California Northstate University, College of Pharmacy, California, USA
Founder
Oncovask Therapeutics LLC, California, USA
Research Interests
- DNA damage repair and replication stress in cancer
- Pharmacology of therapeutic resistance
- RNA-based therapeutics and nanoparticle delivery systems
- Microfluidic tumor modeling and diagnostic platforms
- Biomarker-guided therapy for rare cancers
- Neurodegeneration and DNA repair dysfunction
- Early Cancer Diagnosis
- AI and VR based Predictive oncology and computational modeling
- Call: 916-686-7396
- Email: md.ibrahim@cnsu.edu
Biography
Dr. Md Ibrahim is an Assistant Professor of Pharmacology, Cancer Biology, and Pharmaceutical Science at California Northstate University College of Pharmacy and founder of Oncovask Therapeutics LLC. His research focuses on overcoming cancer therapy resistance by targeting DNA damage repair pathways and replication stress responses.
He develops RNA-based therapeutics, including siRNA-loaded lipid nanoparticles, to silence undruggable DNA repair and checkpoint factors in glioblastoma, ovarian, and breast cancers. His work integrates proximity labeling (Split-TurboID), proteomics, and mechanistic studies of base excision repair and replication stress to restore sensitivity to PARP inhibitors, temozolomide, and alkylating agents.
Dr. Ibrahim also leads precision medicine efforts to repurpose FDA-approved drugs for rare cancers, investigates dormancy and metastasis in breast cancer using microfluidic tumor-on-chip models, and studies DNA repair dysfunction in neurodegenerative diseases such as ALS. His laboratory develops microfluidic and immunofluorescence-based diagnostic platforms for circulating tumor cell detection and precision monitoring.
In collaboration with experts in data science and materials science, he is building predictive oncology models that integrate omics and clinical datasets to personalize cancer treatment.
Education
2022
Ph.D. in Biomedical Sciences (Cancer Biology)
University of South Alabama, Whiddon College of Medicine, Department of Pharmacology, Mitchell Cancer Institute, Molecular and Metabolic Oncology Program
2013
Masters of Pharmaceutical Science
Bangladesh
2011
Bachelor of Pharmaceutical Science
Bangladesh
Discoveries in Cancer, DNA Repair, and Therapeutics
Replication-associated base excision repair/single-strand break repair regulates PARG inhibitor response via the PRMT1/PRMT5/ATR axis
Authors: Ibrahim, M., Roos, W. P., Schwartz, J. C., Khan, M. M., Al-Rahahleh, R. Q., Beers, L. A., Pearson, C. R., Langham, K. T., Boyang, L., Clark, J., Hayat, F., Fang, Q., Koczur, C. A., Migaud, M. E., & Sobol, R. W.
TRIP12's role in the governance of DNA polymerase β involvement in DNA damage response and repair
Authors: Inanc, B., Fang, Q., Roos, W. P., Andrews, J. F., Zeng, X., Clark, J., Li, J., Dey, N. B., Ibrahim, M., Sykora, P., Yu, Z., Pearson, C. R., Braganza, A., Verheij, M., Jonkers, J., Yates, N. A., Vens, C., & Sobol, R. W.
DOI: 10.1093/nar/gkaf574
Nerandomilast as the first PDE4B-selective therapy inidiopathicpulmonaryfibrosis
Authors: Ibrahim, M., Piazza, G. A., & Ahsan, F.
Image cytometry-based quantification protocol of human pulmonary arterial endothelial cells in lab-fabricated multichannel microfluidic devices
Authors: Ibrahim, M., Moinuddin, S. M., Hossain, M. S., Nguyen, T., Sarkar, T., El-Shamy, A., Cucullo, L., Lahm, T., Nozik, E., Simon, M. A., Stenmark, K. R., & Ahsan, F.
Protocol for quantum dot-based cell counting and immunostaining of pulmonary arterial cells from patients with pulmonary arterial hypertension
Authors: Moinuddin, S. M., Ibrahim, M., Sarkar, T., Hossain, M. S., Rose, M., & Ahsan, F.
Regulation of replication-induced PARP1/PARP2 activation by base excision repair: Implications for PARP and PARG inhibitor resistance
Authors: Ibrahim, M., Khan, M. M., Roos, W. P., Al-Rahaleh, R. Q., Hayat, F., Migaud, M. E., & Sobol, R. W.
TRIP12 governs DNA Polymerase β involvement in DNA damage response and repair
Authors: Inanc, B., Fang, Q., Andrews, J. F., Zeng, X., Clark, J., Li, J., Dey, N. B., Ibrahim, M., Sykora, P., Yu, Z., Braganza, A., Verheij, M., Jonkers, J., Yates, N. A., Vens, C., & Sobol, R. W.
Base excision repair regulation of replication stress induced poly(ADP-ribose) checkpoints
Authors: Ibrahim, M., Khan, M. M., Al-Rahaleh, R. Q., Clark, J., Hayat, F., Fang, Q., Koczor, C. A., Migaud, M. E., & Sobol, R. W.
A specific inhibitor of ALDH1A3 regulates retinoic acid biosynthesis in glioma stem cells
Authors: Li, J., Garavaglia, S., Ye, Z., Moretti, A., Belyaeva, O. V., Beiser, A., Ibrahim, M., Wilk, A., McClellan, S., Klyuyeva, A. V., Goggans, K. R., Kedishvili, N. Y., Salter, E. A., Wierzbicki, A., Migaud, M. E., Mullett, S. J., Yates, N. A., Camacho, C. J., Rizzi, M., & Sobol, R. W.
NAD+ bioavailability mediates PARG inhibition-induced replication arrest, intra S-phase checkpoint and apoptosis in glioma stem cells
Authors: Li, J., M Saville, K., Ibrahim, M., Zeng, X., McClellan, S., Angajala, A., Beiser, A., Andrews, J. F., Sun, M., Koczor, C. A., Clark, J., Hayat, F., Makarov, M. V., Wilk, A., Yates, N. A., Migaud, M. E., & Sobol, R. W.
Temporal dynamics of base excision/single-strand break repair protein complex assembly/disassembly are modulated by the PARP/NAD+/SIRT6 axis
Authors: Koczor, C. A., Saville, K. M., Andrews, J. F., Clark, J., Fang, Q., Li, J., Al-Rahahleh, R. Q., Ibrahim, M., McClellan, S., Makarov, M. V., Migaud, M. E., & Sobol, R. W.
Inflammatory cytokines in the pathogenesis of cardiovascular disease and cancer
Authors: Amin, M. N., Siddiqui, S. A., Ibrahim, M., Hakim, M. L., Ahammed, M. S., Kabir, A., & Sultana, F.
Increased Oxidative Stress, Altered Trace Elements, and Macro-Minerals Are Associated with Female Obesity
Authors: Amin, M. N., Siddiqui, S. A., Uddin, M. G., Ibrahim, M., Uddin, S. M. N., Adnan, M. T., Rahaman, M. Z., Kar, A., & Islam, M. S.
Characterization of Transplasma Membrane Electron Transport Chain in Wild and Drug-Resistant Leishmania donovani Promastigote and Amastigote
Authors: Debnath, D., Hossain, M. A., Das, M., Kabir, A., Ibrahim, M., Amin, M. N., Chowdhury, A., & Pervin, R.
An in vivo study of the pharmacological activities of a methanolic acetate fraction of Pistia stratiotes L.: An ethno-medicinal plant used in Bangladesh
Authors: Hussain, M. S., Ibrahim, M., Hasan, M. M., Aziz, M. T., Suchi, S. A., & Uddin, M. G.
DOI: 10.1002/ame2.12037
Therapeutic Potentiality of Diospyros blancoi Linn. Seeds Against Pain, Thrombus and Inflammation: An in vivo and in vitro Study
Authors: Ibrahim, M., Hussain, M. S., Sultana, F., Abhi, N., Ahmed, T., Uddin, S. M. N., Rahaman, A., Azmerin, M., Aka, T. D., Mosharraf, S., & Uddin, A. H. M.
A Study on Ardisia solanacea for Evaluation of Phytochemical and Pharmacological Properties
Authors: Amin, M. N., Banik, S., Ibrahim, M., Moghal, M. M. R., Majumder, M. S., Siddika, R., Alam, M. K., Jitu, K. M. R. M., & Anonna, S. N.